WARS1

Across TCGA patient cohorts, WARS1 mutation is significantly associated with the RNA expression of many other genes, with 2,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WARS1-associated genes across cancer lineages are NOL10, FARSB, and ASNSD1. Each is linked with WARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WARS1-to-partner and partner-to-WARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL10 grouped by WARS1-low versus WARS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS1→partner) and Y-score (partner→WARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NOL10 →	+0.553	+3.478	.005	.002	3	2
SKCM	FARSB →	+0.496	+3.331	.005	.005	3	2
SKCM	ASNSD1 →	+0.631	+3.465	.009	.003	3	2
CESC	RNU6-527P →	+0.218	+4.539	.001	.008	3	2
CESC	RNU6-14P →	+0.257	+4.669	<.001	.007	3	2
UCEC	GPATCH11 →	+0.442	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,095 associations by consensus.

NOL10 by WARS1 expression — SKCM

Explore this box plot interactively →