WARS1

Across TCGA cell cohorts, WARS1 mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WARS1-associated genes across cancer lineages are BLVRA, SH3GL2, and PSMD9. Each is linked with WARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WARS1-to-partner and partner-to-WARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BLVRA grouped by WARS1-low versus WARS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WARS1→partner) and Y-score (partner→WARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BLVRA →	+1.261	+3.299	.006	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+0.970	+3.212	.008	.006	3	1
LARGE_INTESTINE	PSMD9 →	+0.475	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CYP27B1 →	+0.758	+3.212	.004	.006	3	1
LARGE_INTESTINE	KISS1R →	+0.719	+3.299	.008	.004	3	1
LARGE_INTESTINE	WRAP73 →	+0.638	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

BLVRA by WARS1 expression — LARGE_INTESTINE

Explore this box plot interactively →