WAPL

Across TCGA pan-cancer cohorts, WAPL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WAPL data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WAPL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WAPL expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where WAPL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.624	0.953	.002	24	view →
LSCC	DFS	Median	II,III,IV	1.000	0.860	.003	11	view →
GBM	DFS	Tertile	All	0.528	0.197	.007	10	view →
LUAD	DFS	Median	All	0.959	0.875	.026	3	view →
PDAC	DFS	Median	II,III,IV	0.313	0.509	.025	3	view →
CCRCC	DFS	Quartile	III,IV	0.803	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WAPL–HNSC (DFS)

Open the HNSC breakdown →