WAPL

Across TCGA patient cohorts, WAPL mutation is significantly associated with the RNA expression of many other genes, with 5,145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WAPL-associated genes across cancer lineages are RPS3P1, CKS1BP6, and POLE2. Each is linked with WAPL in more than 2 cancer types. Because this analysis shows association rather than direction, both WAPL-to-partner and partner-to-WAPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3P1 grouped by WAPL-low versus WAPL-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAPL→partner) and Y-score (partner→WAPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPS3P1 →	+0.182	+4.308	.006	.007	3	3
SKCM	CKS1BP6 →	+0.275	+2.555	<.001	.003	3	3
UCEC	POLE2 →	+0.563	+1.805	<.001	<.001	3	3
UCEC	SNW1 →	+0.371	+1.420	.002	.002	3	3
UCEC	FANCE →	+0.451	+2.243	.001	.005	3	3
UCEC	CUTC →	+0.375	+2.627	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,145 associations by consensus.

RPS3P1 by WAPL expression — LIHC

Explore this box plot interactively →