WAPL

Across TCGA patient cohorts, WAPL mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WAPL-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and Ku80. Each is linked with WAPL in more than 2 cancer types. Because this analysis shows association rather than direction, both WAPL-to-partner and partner-to-WAPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by WAPL-low versus WAPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAPL→partner) and Y-score (partner→WAPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.128	-1.864	<.001	.002	3	3
UCEC	GAPDH →	+0.583	+3.169	<.001	<.001	3	3
UCEC	Ku80 →	+0.245	+2.183	<.001	<.001	3	3
UCEC	ASNS →	+0.484	+2.392	<.001	<.001	3	3
UCEC	FoxM1 →	+0.196	+1.643	.014	.003	3	2
UCEC	JNK2 →	+0.275	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

FOXO3a_pS318_S321 by WAPL expression — UCEC

Explore this box plot interactively →