WAPL

Across TCGA cell cohorts, WAPL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,003 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WAPL-associated GO terms across cancer lineages are Spindle elongation, Regulation of sister chromatid cohesion, and Phosphatidylinositol metabolic process. Each is linked with WAPL in more than 16 cancer types. Because this analysis shows association rather than direction, both WAPL-to-partner and partner-to-WAPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by WAPL-low versus WAPL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WAPL→partner) and Y-score (partner→WAPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Spindle elongation →	+0.302	+0.530	.004	.003	3	17
BONE	Regulation of sister chromatid cohesion →	+0.131	+0.492	.005	.009	3	16
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.057	+0.880	<.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair via nonhomologous end joining →	+0.055	+0.830	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance in response to DNA damage →	+0.084	+0.666	<.001	.001	3	15
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.118	+0.601	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,003 associations by consensus.

Spindle elongation by WAPL expression — BONE

Explore this box plot interactively →