WAPL

Across TCGA cell cohorts, WAPL mutation is significantly associated with the RNA expression of many other genes, with 494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WAPL-associated genes across cancer lineages are PROP1, KRTAP12-3, and TSSK1B. Each is linked with WAPL in more than 1 cancer types. Because this analysis shows association rather than direction, both WAPL-to-partner and partner-to-WAPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by WAPL-low versus WAPL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WAPL→partner) and Y-score (partner→WAPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.032	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	FAM236A →	+0.126	+5.269	<.001	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.059	+2.043	.003	.008	3	1
LARGE_INTESTINE	SNU13 →	+0.433	+2.743	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 494 associations by consensus.

PROP1 by WAPL expression — BLOOD_Leukemia

Explore this box plot interactively →