WAC

Across TCGA pan-cancer cohorts, WAC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WAC data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher WAC mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WAC expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

GBM, HNSC, and PDAC are the cancer types where WAC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.593	0.279	.003	15	view →
HNSC	OS	Median	All	0.608	0.815	.008	12	view →
PDAC	OS	Median	IV	0.937	0.395	.026	5	view →
UCEC	DFS	Median	II,III,IV	0.882	0.533	.035	4	view →
LUAD	DFS	Tertile	III,IV	0.983	0.570	.027	1	view →
CCRCC	DFS	Median	II,III,IV	0.715	0.510	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WAC–GBM (OS)

Open the GBM breakdown →