WAC-AS1

Across TCGA pan-cancer cohorts, WAC-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated WAC-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher WAC-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WAC-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

LIHC, ACC, and SKCM are the cancer types where WAC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.330	0.534	<.001	76	view →
ACC	DFS	Median	All	0.404	0.756	<.001	71	view →
SKCM	OS	Median	All	0.394	0.280	<.001	60	view →
LGG	OS	Median	All	0.578	0.333	<.001	47	view →
PAAD	DFS	Median	All	0.348	0.220	.003	43	view →
UCS	OS	Tertile	III,IV	0.684	0.202	.008	36	view →
CHOL	OS	Quartile	All	0.903	0.419	.003	24	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	24	view →
KIRC	OS	Median	All	0.844	0.766	.007	22	view →
BRCA	OS	Median	All	0.511	0.660	.003	20	view →
COAD	OS	Quartile	All	0.692	0.892	.005	19	view →
LUSC	OS	Median	II,III,IV	0.803	0.652	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

WAC-AS1–LIHC (DFS)

Open the LIHC breakdown →