WAC-AS1

Across TCGA pan-cancer cohorts, WAC-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of WAC-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where WAC-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types WAC-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where WAC-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WAC-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.668	<.001	10	view →
THCA	Male	III,IV	−0.767	<.001	10	view →
LIHC	Male	II,III,IV	+1.104	<.001	9	view →
HNSC	All	III,IV	+0.465	.001	8	view →
LUSC	Female	All	+0.854	<.001	4	view →
STAD	All	All	+0.618	.001	4	view →
CHOL	Male	All	+2.153	<.001	3	view →
COAD	Female	All	−0.430	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

WAC-AS1–KICH

Open the KICH breakdown →