VXN

Across TCGA patient cohorts, VXN mutation is significantly associated with the RNA expression of many other genes, with 683 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VXN-associated genes across cancer lineages are HIGD1AP3, LINC01874, and MTND3P2. Each is linked with VXN in more than 1 cancer types. Because this analysis shows association rather than direction, both VXN-to-partner and partner-to-VXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1AP3 grouped by VXN-low versus VXN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VXN→partner) and Y-score (partner→VXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HIGD1AP3 →	+0.271	+6.144	<.001	.001	3	2
COAD	LINC01874 →	+0.166	+5.893	<.001	.002	3	2
UCEC	MTND3P2 →	+0.183	+2.852	<.001	.003	3	2
UCEC	MIR5708 →	+0.178	+3.374	<.001	.003	3	2
CESC	UGT1A13P →	+0.095	+5.010	<.001	.009	3	1
CESC	NDUFA4P2 →	+0.277	+5.669	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 683 associations by consensus.

HIGD1AP3 by VXN expression — CESC

Explore this box plot interactively →