VXN

Across TCGA pan-cancer cohorts, VXN RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated VXN data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher VXN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VXN expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

UCEC, LUAD, and LIHC are the cancer types where VXN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.818	0.920	<.001	82	view →
LUAD	OS	Tertile	All	0.789	0.619	<.001	57	view →
LIHC	OS	Tertile	All	0.756	0.610	.005	37	view →
SKCM	DFS	Quartile	All	0.643	0.509	.006	33	view →
LAML	DFS	Median	All	0.317	0.596	<.001	30	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	28	view →
READ	OS	Quartile	All	0.830	1.000	.003	23	view →
KIRC	DFS	Tertile	III,IV	0.227	0.612	.003	22	view →
MESO	DFS	Tertile	III,IV	0.144	0.773	.010	15	view →
UVM	OS	Quartile	All	0.933	0.549	.005	14	view →
STAD	OS	Median	II,III,IV	0.608	0.788	.018	13	view →
KIRP	DFS	Quartile	All	0.897	0.555	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

VXN–UCEC (OS)

Open the UCEC breakdown →