VXN

Across TCGA patient cohorts, VXN mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VXN-associated genes across cancer lineages are ASNS, ERK2, and Myosin-IIa_pS1943. Each is linked with VXN in more than 1 cancer types. Because this analysis shows association rather than direction, both VXN-to-partner and partner-to-VXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VXN-low versus VXN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VXN→partner) and Y-score (partner→VXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.662	+3.321	<.001	.009	3	2
UCEC	ERK2 →	+0.184	+2.000	.034	.032	3	1
UCEC	Myosin-IIa_pS1943 →	+0.189	+2.013	.042	.018	3	1
UCEC	PDCD4 →	-0.439	-2.700	.038	.006	3	1
UCEC	4E-BP1_pT37_T46 →	-0.362	-2.700	.032	.006	3	1
UCEC	PDK1_pS241 →	+0.236	+2.713	.002	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ASNS by VXN expression — UCEC

Explore this box plot interactively →