VXN

Across TCGA cell cohorts, VXN mutation is significantly associated with the mutation status of many other genes, with 42 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible VXN-associated genes across cancer lineages are HOXD12, ZNF131, and TLR10. Each is linked with VXN in more than 1 cancer types. Because this analysis shows association rather than direction, both VXN-to-partner and partner-to-VXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXD12 grouped by VXN-low versus VXN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VXN→partner) and Y-score (partner→VXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HOXD12 →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	ZNF131 →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	TLR10 →	+4.772	+5.339	.004	.004	1	1
LUNG_NSCLC_LUAD	CEP135 →	+4.187	+5.000	.008	.008	1	1
LUNG_NSCLC_LUAD	RBMXL3 →	+4.187	+5.000	.008	.008	1	1
LUNG_NSCLC_LUAD	JAKMIP2 →	+5.772	+5.772	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

HOXD12 by VXN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →