VWF

Across TCGA pan-cancer cohorts, VWF Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated VWF data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher VWF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VWF expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

THYM, MESO, and READ are the cancer types where VWF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
MESO	OS	Median	III,IV	0.160	0.573	.001	36	view →
READ	OS	Median	II,III,IV	0.533	0.942	<.001	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
STAD	DFS	Median	All	0.720	0.380	.024	13	view →
UCEC	DFS	Median	All	0.767	0.629	.007	10	view →
BRCA	OS	Median	II,III,IV	0.366	0.569	.007	8	view →
SKCM	DFS	Median	IV	1.000	0.209	.005	7	view →
SARC	DFS	Median	All	0.085	0.600	<.001	6	view →
BLCA	DFS	Median	IV	0.177	0.481	.040	6	view →
LUSC	DFS	Median	II,III,IV	0.183	0.566	.014	5	view →
LUAD	DFS	Median	II,III,IV	1.000	0.628	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

VWF–THYM (OS)

Open the THYM breakdown →