VWF

Across TCGA pan-cancer cohorts, VWF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VWF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VWF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VWF is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LIHC are the cancer types where VWF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+3.760	<.001	12	view →
LUAD	Female	III,IV	−2.614	<.001	9	view →
LIHC	Female	All	+2.390	<.001	9	view →
LUSC	Female	II,III,IV	−3.001	<.001	7	view →
BRCA	All	II,III,IV	−1.771	<.001	6	view →
KICH	All	II,III,IV	+1.736	<.001	6	view →
KIRP	All	All	+0.679	.014	5	view →
STAD	All	All	+0.705	.015	4	view →
HNSC	Female	III,IV	+1.265	.011	3	view →
READ	Male	All	+1.420	.006	2	view →
UCEC	All	All	−1.322	.003	2	view →
BLCA	All	All	−0.678	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VWF–KIRC

Open the KIRC breakdown →