VWF

Across TCGA pan-cancer cohorts, VWF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VWF data layer compared with 24 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VWF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated VWF expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where VWF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.861	0.972	.015	16	view →
PDAC	OS	Median	All	0.571	0.298	.001	11	view →
HNSC	OS	Median	II,III,IV	0.950	1.000	.014	9	view →
LSCC	DFS	Median	All	0.869	1.000	.003	8	view →
CCRCC	OS	Median	III,IV	0.908	0.727	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VWF–LUAD (DFS)

Open the LUAD breakdown →