VWF

Across TCGA patient cohorts, VWF mutation is significantly associated with the RNA expression of many other genes, with 7,869 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWF-associated genes across cancer lineages are EME1, RAD54L, and BUB3. Each is linked with VWF in more than 5 cancer types. Because this analysis shows association rather than direction, both VWF-to-partner and partner-to-VWF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by VWF-low versus VWF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWF→partner) and Y-score (partner→VWF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.421	+1.222	<.001	<.001	3	6
UCEC	RAD54L →	+0.454	+1.800	.001	<.001	3	6
STAD	BUB3 →	+0.602	+2.923	<.001	<.001	3	5
UCEC	RACGAP1 →	+0.472	+2.136	<.001	<.001	3	5
UCEC	UQCRH →	+0.503	+1.457	.005	<.001	3	5
UCEC	E2F2 →	+0.555	+1.332	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,869 associations by consensus.

EME1 by VWF expression — UCEC

Explore this box plot interactively →