VWF

Across TCGA patient cohorts, VWF mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWF-associated genes across cancer lineages are GAPDH, Cyclin-B1, and PKC-b-II_pS660. Each is linked with VWF in more than 3 cancer types. Because this analysis shows association rather than direction, both VWF-to-partner and partner-to-VWF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by VWF-low versus VWF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWF→partner) and Y-score (partner→VWF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.589	+2.906	<.001	.001	3	4
UCEC	Cyclin-B1 →	+0.559	+2.874	<.001	<.001	3	4
COAD	PKC-b-II_pS660 →	-0.330	-2.321	.001	.005	3	4
LUSC	14-3-3_beta →	-0.086	-2.074	.029	.016	3	3
STAD	eIF4E →	+0.176	+3.021	.016	.017	3	3
STAD	FASN →	+0.498	+2.337	.003	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

GAPDH by VWF expression — COAD

Explore this box plot interactively →