VWF

Across TCGA cell cohorts, VWF mutation is significantly associated with the RNA expression of many other genes, with 1,248 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWF-associated genes across cancer lineages are JOSD1, ZNF66, and PISD. Each is linked with VWF in more than 2 cancer types. Because this analysis shows association rather than direction, both VWF-to-partner and partner-to-VWF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by VWF-low versus VWF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWF→partner) and Y-score (partner→VWF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JOSD1 →	+0.421	+2.222	.004	.001	3	3
LARGE_INTESTINE	ZNF66 →	-0.700	-2.000	<.001	<.001	3	3
LARGE_INTESTINE	PISD →	+0.399	+1.792	.009	<.001	3	3
LARGE_INTESTINE	LRRC40 →	+0.527	+2.700	<.001	<.001	3	3
SOFT_TISSUE	OR10A4 →	+0.181	+4.635	<.001	.003	3	2
SKIN	MBD3L5 →	+0.010	+2.678	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,248 associations by consensus.

JOSD1 by VWF expression — LARGE_INTESTINE

Explore this box plot interactively →