VWDE

Across TCGA patient cohorts, VWDE mutation is significantly associated with the RNA expression of many other genes, with 3,826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWDE-associated genes across cancer lineages are LINC02559, OR1D4, and MIR3944. Each is linked with VWDE in more than 2 cancer types. Because this analysis shows association rather than direction, both VWDE-to-partner and partner-to-VWDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by VWDE-low versus VWDE-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWDE→partner) and Y-score (partner→VWDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	3
BRCA	OR1D4 →	+0.029	+4.385	<.001	.001	3	2
BRCA	MIR3944 →	+0.416	+3.131	.002	.007	3	2
UCEC	CCL5 →	+1.107	+2.874	<.001	<.001	3	2
UCEC	TAF9 →	+0.543	+1.959	<.001	<.001	3	2
UCEC	CCL4 →	+0.832	+1.980	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,826 associations by consensus.

LINC02559 by VWDE expression — CESC

Explore this box plot interactively →