VWCE

Across TCGA patient cohorts, VWCE mutation is significantly associated with the RNA expression of many other genes, with 2,259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWCE-associated genes across cancer lineages are CDC45, PPP2R5D, and MFN2. Each is linked with VWCE in more than 2 cancer types. Because this analysis shows association rather than direction, both VWCE-to-partner and partner-to-VWCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by VWCE-low versus VWCE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWCE→partner) and Y-score (partner→VWCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDC45 →	+0.865	+3.594	<.001	.001	3	3
UCEC	PPP2R5D →	+0.516	+2.338	<.001	.003	3	3
UCEC	MFN2 →	+0.513	+1.839	<.001	.002	3	3
UCEC	GINS2 →	+0.657	+2.807	.001	.003	3	3
SKCM	PSMC3IP →	+0.762	+3.469	<.001	.002	3	3
HNSC	RPL21P31 →	+0.133	+4.295	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,259 associations by consensus.

CDC45 by VWCE expression — SKCM

Explore this box plot interactively →