VWCE

Across TCGA patient cohorts, VWCE mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWCE-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with VWCE in more than 1 cancer types. Because this analysis shows association rather than direction, both VWCE-to-partner and partner-to-VWCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by VWCE-low versus VWCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWCE→partner) and Y-score (partner→VWCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.360	-3.700	.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-2.115	.006	.016	3	2
UCEC	mTOR_pS2448 →	-0.178	-3.794	<.001	<.001	3	2
UCEC	mTOR →	-0.162	-1.925	.005	.005	3	2
UCEC	Cyclin-B1 →	+0.517	+2.584	.010	.010	3	2
BLCA	MEK1_p_S217_S221 →	+0.507	+2.824	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

INPP4B by VWCE expression — UCEC

Explore this box plot interactively →