VWCE

Across TCGA cell cohorts, VWCE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,619 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VWCE-associated GO terms across cancer lineages are mRNA catabolic process, Regulation of transcription by RNA polymerase I, and RNA catabolic process. Each is linked with VWCE in more than 10 cancer types. Because this analysis shows association rather than direction, both VWCE-to-partner and partner-to-VWCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA catabolic process grouped by VWCE-low versus VWCE-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VWCE→partner) and Y-score (partner→VWCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	mRNA catabolic process →	+0.054	+1.301	<.001	<.001	3	11
BONE	Regulation of transcription by RNA polymerase I →	+0.105	+1.509	<.001	<.001	3	11
BONE	RNA catabolic process →	+0.060	+1.693	<.001	<.001	3	10
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.135	+1.478	<.001	<.001	3	10
BONE	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.139	+1.969	<.001	<.001	3	9
LARGE_INTESTINE	Positive regulation of transcription by RNA polymerase I →	+0.099	+0.801	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,619 associations by consensus.

mRNA catabolic process by VWCE expression — LUNG_SCLC

Explore this box plot interactively →