Across TCGA patient cohorts, VWC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,287 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VWC2-associated proteins across cancer lineages are SYNPO2, YBX1_S165, and SORBS1. Each is linked with VWC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both VWC2-to-partner and partner-to-VWC2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (VWC2→partner) and Y-score (partner→VWC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2 →	+0.662	+0.352	<.001	<.001	3	5
LUAD	YBX1_S165 →	-0.627	-0.072	<.001	.001	3	4
UCEC	SORBS1 →	+0.712	+0.327	<.001	.001	3	4
UCEC	ADD1 →	+0.345	+0.345	<.001	<.001	3	4
LUAD	CAD_S1859 →	-0.405	-0.053	.002	.002	3	4
UCEC	CNRIP1 →	+1.148	+0.520	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,287 associations by consensus.

Exploration

VWC2 survival (RNA) · tumor vs normal (RNA) · all VWC2 data types