VWA8

Across TCGA pan-cancer cohorts, VWA8 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated VWA8 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher VWA8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VWA8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, BRCA, and UCEC are the cancer types where VWA8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BRCA	OS	Median	All	0.269	0.925	<.001	35	view →
UCEC	DFS	Median	All	0.936	0.591	<.001	34	view →
LUAD	OS	Median	II,III,IV	0.074	0.712	<.001	33	view →
PAAD	OS	Median	All	0.087	0.640	<.001	24	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
LIHC	OS	Median	All	0.031	0.775	<.001	11	view →
PRAD	DFS	Median	All	0.617	0.886	.036	6	view →
STAD	OS	Median	II,III,IV	0.925	0.663	.026	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LGG	OS	Median	All	0.317	0.799	.015	3	view →
HNSC	OS	Median	All	0.494	0.770	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

VWA8–THYM (OS)

Open the THYM breakdown →