VWA8

Across TCGA pan-cancer cohorts, VWA8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VWA8 data layer compared with 20 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VWA8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VWA8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where VWA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	1.000	0.817	.007	9	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	3	view →
LSCC	DFS	Median	II,III,IV	0.444	0.883	.030	1	view →
GBM	DFS	Median	All	0.783	0.579	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VWA8–LUAD (DFS)

Open the LUAD breakdown →