VWA8

Across TCGA patient cohorts, VWA8 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA8-associated genes across cancer lineages are Caspase-7-cleavedD198, p38-MAPK_pT180_Y182, and eIF4E. Each is linked with VWA8 in more than 3 cancer types. Because this analysis shows association rather than direction, both VWA8-to-partner and partner-to-VWA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by VWA8-low versus VWA8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA8→partner) and Y-score (partner→VWA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.193	+3.016	<.001	.018	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.295	-1.074	.010	.010	3	3
COAD	eIF4E →	+0.237	+3.182	.003	.009	3	3
UCEC	FASN →	+0.241	+0.830	.017	.049	3	3
UCEC	INPP4B →	-0.241	-1.836	.003	<.001	3	3
COAD	JNK_pT183_Y185 →	-0.256	-3.000	.029	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Caspase-7-cleavedD198 by VWA8 expression — COAD

Explore this box plot interactively →