VWA8-AS1

Across TCGA pan-cancer cohorts, VWA8-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VWA8-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VWA8-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types VWA8-AS1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where VWA8-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWA8-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.404	<.001	11	view →
THCA	Male	All	−0.287	<.001	11	view →
KICH	Male	All	−0.613	<.001	10	view →
LUAD	Female	All	−0.361	<.001	8	view →
HNSC	Male	All	+0.279	.005	5	view →
KIRP	Male	All	−0.242	<.001	5	view →
LIHC	Male	All	+0.105	.016	3	view →
UCEC	All	All	−0.269	.038	2	view →
PRAD	All	All	−0.130	<.001	2	view →
COAD	All	All	+0.035	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VWA8-AS1–KIRC

Open the KIRC breakdown →