VWA5B1

Across TCGA pan-cancer cohorts, VWA5B1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VWA5B1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher VWA5B1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VWA5B1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, UCEC, and LIHC are the cancer types where VWA5B1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.074	0.703	<.001	36	view →
UCEC	DFS	Median	All	0.947	0.628	.012	16	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VWA5B1–ESCA (OS)

Open the ESCA breakdown →