VWA5B1

Across TCGA pan-cancer cohorts, VWA5B1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of VWA5B1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where VWA5B1 RNA is repressed in tumor relative to normal tissue. In most cancer types VWA5B1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where VWA5B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWA5B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.450	<.001	12	view →
KIRP	Male	All	−1.458	<.001	9	view →
LUSC	All	II,III,IV	−0.144	<.001	5	view →
STAD	All	All	+0.435	.012	4	view →
LUAD	Male	II,III,IV	−0.133	.002	2	view →
KICH	All	All	+0.714	.026	1	view →
THCA	Male	IV	−0.286	.015	1	view →
READ	All	All	−0.212	.019	1	view →
BRCA	Female	II,III,IV	−0.032	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

VWA5B1–KIRC

Open the KIRC breakdown →