VWA5B1

Across TCGA patient cohorts, VWA5B1 mutation is significantly associated with the RNA expression of many other genes, with 6,743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA5B1-associated genes across cancer lineages are KLRD1, ZSWIM3, and RNA5SP289. Each is linked with VWA5B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA5B1-to-partner and partner-to-VWA5B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRD1 grouped by VWA5B1-low versus VWA5B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5B1→partner) and Y-score (partner→VWA5B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLRD1 →	+0.257	+2.223	<.001	<.001	3	3
COAD	ZSWIM3 →	-0.768	-3.690	<.001	.001	3	2
CESC	RNA5SP289 →	+0.137	+3.539	<.001	<.001	3	2
UCEC	PSAT1P4 →	+0.097	+1.496	.001	<.001	3	2
CESC	THAP12P4 →	+0.007	+3.227	.001	.005	3	2
CESC	RPL34P36 →	+0.043	+3.227	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,743 associations by consensus.

KLRD1 by VWA5B1 expression — UCEC

Explore this box plot interactively →