VWA5B1

Across TCGA cell cohorts, VWA5B1 mutation is significantly associated with the RNA expression of many other genes, with 1,153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWA5B1-associated genes across cancer lineages are COMMD2, CAPN7, and JOSD1. Each is linked with VWA5B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA5B1-to-partner and partner-to-VWA5B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COMMD2 grouped by VWA5B1-low versus VWA5B1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5B1→partner) and Y-score (partner→VWA5B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COMMD2 →	+0.431	+2.043	.009	.008	3	3
LARGE_INTESTINE	CAPN7 →	+0.630	+2.743	<.001	.001	3	3
LARGE_INTESTINE	JOSD1 →	+0.613	+3.459	<.001	.001	3	2
LARGE_INTESTINE	METTL4 →	+0.630	+2.043	<.001	.008	3	2
LARGE_INTESTINE	PIGL →	+0.636	+3.321	.004	.003	3	2
LARGE_INTESTINE	UBE2D3 →	+0.474	+2.043	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,153 associations by consensus.

COMMD2 by VWA5B1 expression — LARGE_INTESTINE

Explore this box plot interactively →