VWA5A

Across TCGA pan-cancer cohorts, VWA5A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VWA5A data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VWA5A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VWA5A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where VWA5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.655	0.433	<.001	93	view →
LSCC	DFS	Quartile	II,III,IV	0.456	0.933	.003	10	view →
LUAD	DFS	Median	II,III,IV	0.745	0.961	.010	4	view →
GBM	OS	Tertile	All	0.716	0.910	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VWA5A–PDAC (OS)

Open the PDAC breakdown →