VWA5A

Across TCGA pan-cancer cohorts, VWA5A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of VWA5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VWA5A RNA is repressed in tumor relative to normal tissue. In most cancer types VWA5A is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where VWA5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWA5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.635	<.001	12	view →
KIRC	Male	III,IV	−1.085	<.001	12	view →
KICH	Male	III,IV	−2.830	<.001	11	view →
LUSC	Male	II,III,IV	−1.496	<.001	8	view →
HNSC	Male	II,III,IV	−1.042	<.001	8	view →
READ	Male	All	−1.650	<.001	7	view →
THCA	Male	All	+0.409	<.001	7	view →
BLCA	Male	All	−1.687	.001	6	view →
UCEC	All	All	−1.321	<.001	6	view →
BRCA	All	II,III,IV	−0.873	<.001	6	view →
CHOL	All	All	+1.460	<.001	4	view →
LUAD	All	All	−0.296	.015	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

VWA5A–COAD

Open the COAD breakdown →