VWA5A

Across TCGA patient cohorts, VWA5A mutation is significantly associated with the RNA expression of many other genes, with 2,936 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA5A-associated genes across cancer lineages are TUB, RNA5SP412, and TAFA5. Each is linked with VWA5A in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA5A-to-partner and partner-to-VWA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUB grouped by VWA5A-low versus VWA5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5A→partner) and Y-score (partner→VWA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUB →	-0.699	-3.978	<.001	<.001	3	3
UCEC	RNA5SP412 →	+0.566	+1.902	<.001	<.001	3	3
UCEC	TAFA5 →	-0.779	-2.313	.003	.001	3	3
LUSC	HPRT1P2 →	+0.103	+3.882	<.001	.002	3	3
COAD	RNU5E-8P →	+0.370	+4.821	<.001	.003	3	3
UCEC	ADAM33 →	-0.866	-3.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,936 associations by consensus.

TUB by VWA5A expression — UCEC

Explore this box plot interactively →