VWA5A

Across TCGA cell cohorts, VWA5A mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VWA5A-associated genes across cancer lineages are GOLGA6L6, IFNK, and IQCF5. Each is linked with VWA5A in more than 1 cancer types. Because this analysis shows association rather than direction, both VWA5A-to-partner and partner-to-VWA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L6 grouped by VWA5A-low versus VWA5A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA5A→partner) and Y-score (partner→VWA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GOLGA6L6 →	+0.019	+4.044	.006	.009	3	2
CNS	IFNK →	+0.117	+3.874	<.001	<.001	3	2
BLOOD_Lymphoma	IQCF5 →	+0.092	+4.058	<.001	.009	3	2
LARGE_INTESTINE	SCO1 →	+0.655	+3.169	.001	.009	3	2
SKIN	CARTPT →	+0.036	+5.009	<.001	<.001	3	1
SKIN	CASP12 →	+0.051	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

GOLGA6L6 by VWA5A expression — LUNG_SCLC

Explore this box plot interactively →