VWA3B

Across TCGA pan-cancer cohorts, VWA3B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VWA3B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where VWA3B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VWA3B is over-expressed in tumor.

LSCC, LUAD, and COAD are the cancer types where VWA3B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VWA3B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+1.974	<.001	8	view →
LUAD	Male	All	+0.905	<.001	5	view →
COAD	All	II,III,IV	+1.873	<.001	4	view →
PDAC	Female	III,IV	+1.715	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

VWA3B–LSCC

Open the LSCC breakdown →