VWA3B

Across TCGA patient cohorts, VWA3B mutation is significantly associated with the RNA expression of many other genes, with 5,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA3B-associated genes across cancer lineages are CDCA8, TCF19, and KIF23. Each is linked with VWA3B in more than 4 cancer types. Because this analysis shows association rather than direction, both VWA3B-to-partner and partner-to-VWA3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA8 grouped by VWA3B-low versus VWA3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3B→partner) and Y-score (partner→VWA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA8 →	+0.546	+2.364	<.001	<.001	3	5
UCEC	TCF19 →	+0.604	+1.490	<.001	<.001	3	5
UCEC	KIF23 →	+0.517	+2.147	<.001	<.001	3	5
UCEC	CENPU →	+0.627	+1.820	<.001	<.001	3	4
UCEC	SAR1B →	+0.368	+1.624	<.001	<.001	3	4
STAD	SMIM12 →	+0.304	+3.233	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,198 associations by consensus.

CDCA8 by VWA3B expression — UCEC

Explore this box plot interactively →