VWA3B

Across TCGA patient cohorts, VWA3B mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA3B-associated genes across cancer lineages are Cyclin-B1, PCNA, and Caspase-7-cleavedD198. Each is linked with VWA3B in more than 4 cancer types. Because this analysis shows association rather than direction, both VWA3B-to-partner and partner-to-VWA3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by VWA3B-low versus VWA3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3B→partner) and Y-score (partner→VWA3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.554	+3.087	<.001	<.001	3	5
LUSC	PCNA →	+0.197	+1.494	.010	.035	3	4
UCEC	Caspase-7-cleavedD198 →	+0.522	+1.534	.001	.008	3	4
SKCM	ACC_pS79 →	+0.206	+1.392	.030	.018	3	3
UCEC	JNK2 →	+0.215	+2.080	<.001	<.001	3	3
UCEC	Rab25 →	-0.352	-3.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Cyclin-B1 by VWA3B expression — UCEC

Explore this box plot interactively →