VWA3A

Across TCGA patient cohorts, VWA3A mutation is significantly associated with the RNA expression of many other genes, with 3,572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA3A-associated genes across cancer lineages are RPL22P22, RARRES2P5, and CHEK1. Each is linked with VWA3A in more than 2 cancer types. Because this analysis shows association rather than direction, both VWA3A-to-partner and partner-to-VWA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P22 grouped by VWA3A-low versus VWA3A-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3A→partner) and Y-score (partner→VWA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPL22P22 →	+0.139	+4.248	<.001	.001	3	3
LIHC	RARRES2P5 →	+0.047	+4.149	<.001	.009	3	3
UCEC	CHEK1 →	+0.605	+2.345	<.001	<.001	3	3
UCEC	MON1A →	+0.262	+1.936	.002	.002	3	3
UCEC	HIRA →	+0.382	+1.928	<.001	<.001	3	3
UCEC	PLEKHJ1 →	+0.571	+2.157	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

RPL22P22 by VWA3A expression — LIHC

Explore this box plot interactively →