VWA3A

Across TCGA patient cohorts, VWA3A mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VWA3A-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and PKC-b-II_pS660. Each is linked with VWA3A in more than 3 cancer types. Because this analysis shows association rather than direction, both VWA3A-to-partner and partner-to-VWA3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by VWA3A-low versus VWA3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VWA3A→partner) and Y-score (partner→VWA3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.284	+2.700	<.001	.005	3	4
UCEC	Caspase-7-cleavedD198 →	+0.597	+1.267	.001	.026	3	3
STAD	PKC-b-II_pS660 →	-0.471	-3.169	.006	.019	3	2
UCEC	EGFR_pY1068 →	-0.159	-1.502	.044	.027	3	2
UCEC	ACC_pS79 →	+0.261	+1.290	.016	.034	3	2
UCEC	PCNA →	+0.161	+1.137	.017	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

4E-BP1 by VWA3A expression — UCEC

Explore this box plot interactively →