VTRNA2-1

Across TCGA pan-cancer cohorts, VTRNA2-1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated VTRNA2-1 data layer compared with 3 for mutation status.

The strongest signal is observed in thymoma (THYM), where higher VTRNA2-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VTRNA2-1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.

THYM, UVM, and LGG are the cancer types where VTRNA2-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	All	0.292	0.825	<.001	93	view →
UVM	DFS	Tertile	All	0.301	0.694	.001	78	view →
LGG	OS	Tertile	All	0.228	0.484	<.001	48	view →
COAD	OS	Tertile	III,IV	0.556	0.848	<.001	38	view →
STAD	OS	Median	II,III,IV	0.616	0.730	.008	34	view →
MESO	OS	Tertile	All	0.170	0.646	.001	27	view →
KIRC	DFS	Median	IV	0.461	0.720	.018	20	view →
THCA	OS	Tertile	IV	0.878	1.000	.011	18	view →
ESCA	DFS	Tertile	All	0.374	0.902	.009	15	view →
BLCA	OS	Tertile	IV	0.119	0.335	.010	9	view →
LUSC	DFS	Tertile	II,III,IV	0.523	0.721	.028	9	view →
KIRP	OS	Median	All	0.927	0.842	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

VTRNA2-1–THYM (DFS)

Open the THYM breakdown →