VTRNA2-1

Across TCGA pan-cancer cohorts, VTRNA2-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VTRNA2-1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where VTRNA2-1 RNA is repressed in tumor relative to normal tissue. In most cancer types VTRNA2-1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where VTRNA2-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VTRNA2-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.806	<.001	7	view →
KICH	All	All	−0.316	.013	4	view →
LUSC	All	All	−0.304	.003	4	view →
BRCA	All	III,IV	−0.266	.009	4	view →
KIRP	All	III,IV	−0.198	.009	4	view →
STAD	Female	III,IV	+2.375	.010	1	view →
STAD	Male	II,III,IV	−0.685	.049	1	view →
COAD	Female	III,IV	−0.538	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

VTRNA2-1–THCA

Open the THCA breakdown →