VTCN1

Across TCGA patient cohorts, VTCN1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTCN1-associated genes across cancer lineages are Notch1, MEK1, and STAT3_pY705. Each is linked with VTCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VTCN1-to-partner and partner-to-VTCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by VTCN1-low versus VTCN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTCN1→partner) and Y-score (partner→VTCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.191	+3.009	.009	.019	3	2
UCEC	MEK1 →	+0.560	+3.321	.003	.010	3	1
UCEC	STAT3_pY705 →	-0.487	-2.999	<.001	.035	3	1
UCEC	TIGAR →	+0.183	+2.196	.022	.034	3	1
UCEC	ATM →	-0.803	-3.321	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by VTCN1 expression — UCEC

Explore this box plot interactively →