VTCN1

Across TCGA pan-cancer cohorts, VTCN1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VTCN1 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher VTCN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VTCN1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LGG show a favorable association.

DLBC, CESC, and COAD are the cancer types where VTCN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	All	0.201	1.000	.002	77	view →
CESC	OS	Tertile	IV	0.808	0.113	.001	62	view →
COAD	OS	Median	IV	0.336	0.723	<.001	49	view →
BLCA	OS	Tertile	IV	0.326	0.850	<.001	48	view →
SKCM	OS	Median	II,III,IV	0.660	0.807	.001	42	view →
CHOL	DFS	Quartile	All	0.192	0.848	.001	35	view →
LGG	DFS	Median	All	0.808	0.634	<.001	32	view →
PAAD	DFS	Quartile	All	0.197	0.567	.005	22	view →
UCEC	DFS	Quartile	All	0.333	0.738	.008	18	view →
OV	OS	Tertile	All	0.901	0.797	<.001	14	view →
LUSC	DFS	Tertile	II,III,IV	0.792	0.632	.013	8	view →
TGCT	DFS	Tertile	All	0.538	0.816	.016	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VTCN1–DLBC (OS)

Open the DLBC breakdown →