VTA1

Across TCGA pan-cancer cohorts, VTA1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of VTA1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where VTA1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VTA1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

PDAC, LSCC, and COAD are the cancer types where VTA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VTA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	+0.514	<.001	8	view →
LSCC	Male	All	+0.390	<.001	8	view →
COAD	All	III,IV	+0.109	.001	6	view →
LUAD	Male	All	+0.178	<.001	4	view →
OV	All	All	+0.448	.002	2	view →
CCRCC	Male	All	−0.135	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

VTA1–PDAC

Open the PDAC breakdown →