VTA1

Across TCGA pan-cancer cohorts, VTA1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated VTA1 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VTA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VTA1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

MESO, BLCA, and LIHC are the cancer types where VTA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.408	0.678	<.001	87	view →
BLCA	DFS	Tertile	All	0.458	0.702	.002	55	view →
LIHC	DFS	Quartile	All	0.298	0.467	<.001	52	view →
OV	OS	Tertile	III,IV	0.614	0.726	.008	48	view →
KIRP	DFS	Quartile	All	0.806	0.954	.003	48	view →
KIRC	OS	Median	All	0.707	0.562	.003	44	view →
ACC	DFS	Quartile	All	0.212	0.698	.001	43	view →
THYM	DFS	Quartile	All	0.954	0.607	<.001	32	view →
LUAD	OS	Median	All	0.767	0.852	.005	32	view →
READ	OS	Median	All	0.895	0.318	.003	32	view →
KICH	DFS	Median	II,III,IV	0.571	0.920	.005	31	view →
BRCA	OS	Quartile	All	0.551	0.766	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

VTA1–MESO (OS)

Open the MESO breakdown →