VTA1

Across TCGA patient cohorts, VTA1 mutation is significantly associated with the RNA expression of many other genes, with 721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTA1-associated genes across cancer lineages are RNU1-33P, CCNHP1, and RNU6-1197P. Each is linked with VTA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both VTA1-to-partner and partner-to-VTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-33P grouped by VTA1-low versus VTA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTA1→partner) and Y-score (partner→VTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-33P →	+0.223	+5.797	<.001	.001	3	4
HNSC	CCNHP1 →	+0.064	+5.015	.005	.009	3	3
LUSC	RNU6-1197P →	+0.973	+6.309	<.001	.001	3	3
SKCM	OR5F2P →	+0.053	+5.624	<.001	.002	3	3
SKCM	MTCYBP36 →	+0.115	+5.080	<.001	.004	3	3
SKCM	BNIP3P23 →	+0.065	+5.080	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 721 associations by consensus.

RNU1-33P by VTA1 expression — SKCM

Explore this box plot interactively →