VTA1

Across TCGA patient cohorts, VTA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VTA1-associated genes across cancer lineages are S6_pS235_S236, Caspase-8, and CDK1_pY15. Each is linked with VTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VTA1-to-partner and partner-to-VTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS235_S236 grouped by VTA1-low versus VTA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VTA1→partner) and Y-score (partner→VTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS235_S236 →	+0.720	+3.169	.002	.019	3	1
UCEC	Caspase-8 →	-0.323	-2.973	.019	.035	3	1
UCEC	CDK1_pY15 →	+0.351	+3.191	.002	.010	3	1
UCEC	PCNA →	+0.309	+3.169	.009	.020	1	1
UCEC	Collagen-VI →	-0.306	-3.169	.006	.020	1	1
UCEC	Cyclin-B1 →	+0.880	+3.169	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

S6_pS235_S236 by VTA1 expression — UCEC

Explore this box plot interactively →